Thursday, February 28, 2013

Metabolism

Intermediary metabolism

Glycolysis: A molecule of glucose (a 6-carbon compound ) is degraded in a series of enzyme-catalyzed reactions to yield 2 molecules of pyruvate (a 3-crbon compound). Two molecules of adenosine triphosphate and two molecules of NADH are also produced. This is carried out under anaerobiotic conditions.

The glycolytic break down of glucose to pyruvate is the sole source of metabolic efficiency (ATP) in some mammalian tissues and cells, for example:a) The erythrocytes b) The renal bulb c) sperm

Major pathways of glucose utilization

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Carbohydrates serve as the primary source of energy in the cell, and carbohydrate metabolism

is central to all metabolic processes.

During catabolism, larger biomolecules such as carbohydrates, fats and proteins are broken down to
petite common intermediates such as acetyl CoA, water, carbon dioxide and ammonia.

Homolactic Fermentation

anaerobic breakdown of organic compounds (e.g. pyruvate) by living cells to lactic pungent (lactic acid fermentation) or ethanol (alcoholic fermentation).

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Fathers of Glycolysis

GLYCOLYSIS: The reactions

Glucose Metabolism

Control of glycolysis

Phosphofructokinase-1 which catalyzes the committed spirit in glycolysis, is the most important control site: fructose -6-phosphate + ATP → fructose 1, 6 bisphosphate + ADP This reaction is trigger by F-2, 6 bisphosphate (F-2, 6 BP) and AMP and inhibited by ATP and citrate.

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The tricarboxylic acid pathway, also known as the Krebs stave or the Citric Acid Cycle, is
an aerobic process that occurs in the mitochondria.

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The processes of electron transport and oxidative phosphorylation are two linked
processes which allow the mitochondria to reoxidize NADH and manufacture ATP

TOTAL = 38 ATP PER GLUCOSE (39 FROM animal starch VIA G-1-P)

• Glycolysis
– glucose to fructose-1,6-bisphosphate (-2 ATP) – glyceraldehyde-3-P to 1,3-bisphosphoglycerate +2...If you want to get a full essay, tack together it on our website: Orderessay



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